Monday, April 15, 2019

Clinical Pathology as a Tool to Assess Immunotoxicity


Conference name: 2nd International conference on pathology
Short name: Pathology 2019
Venue: Paris, France | July 5-6,2019
URL: https://bit.ly/2GS09CI



Clinical pathology is a critical part of drug and chemical safety evaluation. The hematology, serum chemistry, and urinalysis evaluations routinely conducted in standard toxicity studies contain numerous parameters which provide information about immune status and function, and additional parameters, such as acute phase proteins, complement, and histamine, may be added to further characterize immune status. This article discusses the various clinical pathology parameters which are useful in identifying effects on the immune system. It also provides guidance for minimizing confounding variables, understanding differences between species, and differentiating stress from direct immunotoxicity. A few examples of clinical pathology findings which suggest immunotoxicity are provided as an aid to data interpretation.

To know more about Pathology and its Applications do attend International Conference on Pathology 2019 http://pathology.alliedacademies.com/


Contact
KRISTIE NOVA
Program Director | PATHOLOGY 2019
Phone: (44) 20 3769 1755
Email: pathology(at)alliedannualsummit(dot)com

Thursday, April 11, 2019

Human-Pathogen Coevolution: Helicobacter Pylori


Conference name: 2nd International conference on pathology
Short name: Pathology 2019
Venue : Paris,France | July 5-6,2019
URL: https://bit.ly/2GS09CI

Helicobacter pylori is a widespread bacterium that colonizes the gut mucosa in nearly half the human population, causing gastric inflammation and, in a small percentage of patients, stomach cancer—the second leading cause of cancer-related deaths worldwide. But the prevalence of H. pylori infections do not correlate with cancer incidence, suggesting other factors are at play. In a study published today (January 13) in PNAS, researchers provide evidence that those other factors include the ancestry of both the host and the pathogen: patients that are infected with H. pylori strains that have a distinct ancestry from their own are more likely to suffer severe disease.





To know more about Pathology and its Applications do attend International Conference on Pathology 2019 http://pathology.alliedacademies.com/

Contact
KRISTIE NOVA
Program Director | PATHOLOGY 2019
Phone: (44) 20 3769 1755
Email: pathology(at)alliedannualsummit(dot)com

Tuesday, April 9, 2019

Zika virus study reveals possible causes of brain pathology

Conference name: 2nd International conference on pathology
Short name: Pathology 2019
Venue : Paris,France | July 5-6,2019
URL: https://bit.ly/2GS09CI

A few years ago, Zika virus spread across South America, posing a health issue with global impact. A significant number of South American women who came into contact with the virus for the first time at the start of their pregnancy by a mosquito bite subsequently gave birth to children with severe disabilities. The babies suffered from a condition known as microcephaly; they were born with a brain that was too small. This can lead to intellectual disabilities and other serious neurological disorders.

Scientists succeeded in proving that these deformities are caused by Zika virus infections, but so far they have been unable to explain why. Andreas Pichlmair, Chair for Viral Immunopathology at TUM, and his team from the TUM Institute of Virology and MPI-B have examined how Zika virus influences human brain cells. They identified the virus proteins with the potential to affect neuronal development in the developing brain.
To know more about Pathology and its Applications do attend International Conference on Pathology 2019 http://pathology.alliedacademies.com/

Contact
KRISTIE NOVA
Program Director | PATHOLOGY 2019
Phone: (44) 20 3769 1755
Email: pathology(at)alliedannualsummit(dot)com

Helicobacter pylori and gastroduodenal pathology


Conference name: 2nd International conference on pathology
Short name: Pathology 2019
Venue : Paris,France | July 5-6,2019
URL: https://bit.ly/2GS09CI


The human gastric pathogen Helicobacter pylori causes chronic gastritis, peptic ulcer disease, gastric carcinoma, and mucosa-associated lymphoid tissue (MALT) lymphoma. It infects over 50% of the worlds' population, however, only a small subset of infected people experience H. pylori-associated illnesses. Associations with disease-specific factors remain enigmatic years after the genome sequences were deciphered. Infection with strains of Helicobacter pylori that carry the cytotoxin-associated antigen A (cagA) gene is associated with gastric carcinoma. 


Author: Niyaz Ahmed
Recent studies revealed mechanisms through which the cagA protein triggers oncopathogenic activities. Other candidate genes such as some members of the so-called plasticity region cluster are also implicated to be associated with carcinoma of stomach. Study of the evolution of polymorphisms and sequence variation in H. pylori populations on a global basis has provided a window into the history of human population migration and co-evolution of this pathogen with its host. Possible symbiotic relationships were debated since the discovery of this pathogen. 


To know more about Pathology and its Applications do attend International Conference on Pathology 2019 http://pathology.alliedacademies.com/

Contact
KRISTIE NOVA
Program Director | PATHOLOGY 2019
Phone: (44) 20 3769 1755
Email: pathology(at)alliedannualsummit(dot)com

Most widely spread coxsackievirus in Shanghai, China


Conference name: 2nd International conference on pathology
Short name: Pathology 2019
Venue : Paris,France | July 5-6,2019
URL: https://bit.ly/2GS09CI

Hand, foot and mouth disease (HFMD) is a transmissible infectious disease caused by human enteroviruses (EV). Here, we described features of children with severe HFMD caused by coxsackievirus A16 (CV-A16) in Shanghai, China. CV-A16 accounted 40.76% of admitted HFMD during 2014 to 2016 in Xinhua Hospital. IVIG appeared to be beneficial in shortening the duration of illness episodes of severe HFMD.Severe CV-A16 caused HFMD children admitted to the Xinhua Hospital from January 2014 and December 2016, were recruited retrospectively to the study. Symptoms and findings at the time of hospitalization, laboratory tests, treatments, length of stay and residual findings at discharge were systematically recorded and analyzed.


Author: Qingli Zhang
To know more about Pathology and its Applications do attend International Conference on Pathology 2019 http://pathology.alliedacademies.com/


Contact
KRISTIE NOVA
Program Director | PATHOLOGY 2019
Phone: (44) 20 3769 1755
Email: pathology(at)alliedannualsummit(dot)com

Monday, April 8, 2019

Tumor Budding and Prognosis in Gastric Adenocarcinoma


Conference name: 2nd International conference on pathology
Short name: Pathology 2019
Venue : Paris,France | July 5-6,2019
URL: https://bit.ly/2GS09CI


Tumor budding has been associated with poor prognosis in several cancer types, but its significance in gastric cancer is unknown. The aim of this study was to assess the prognostic significance of tumor budding in gastric adenocarcinoma, and its main histologic types. Some 583 gastric adenocarcinoma patients who underwent surgery in Oulu University Hospital during the years 1983-2016 were included in this retrospective cohort study. Tumor budding was counted per 0.785 mm2 fields from the slides originally used for diagnostic purposes. Patients were divided into low-budding (<10 buds) and high-budding (≥10 buds) groups. Tumor budding was analyzed in relation to 5-year survival and overall survival. Cox regression was used to calculate hazard ratios (HR) with 95% confidence intervals (CI), adjusted for confounders. 


Author: Niko Kemi
Determining tumor budding was difficult in diffuse-type cancer due to the uncohesive growth pattern of these tumors. Patients with high tumor budding had worse 5-year survival compared with patients with low tumor budding. In intestinal-type adenocarcinomas, the high-budding group had significantly poorer 5-year survival compared with the low-budding group . There were no differences in 5-year survival between the budding groups in the diffuse type adenocarcinoma. In conclusion, high tumor budding is an independent prognostic factor in gastric adenocarcinoma, but its value is limited to the intestinal type of gastric adenocarcinoma. In diffuse type gastric adenocarcinoma, the assessment of tumor budding is hardly feasible, and it does not have prognostic relevance.


To know more about Pathology and its Applications do attend International Conference on Pathology 2019 http://pathology.alliedacademies.com/

Contact
KRISTIE NOVA
Program Director | PATHOLOGY 2019
Phone: (44) 20 3769 1755
Email: pathology(at)alliedannualsummit(dot)com

Stem Cell Transplants for Blood Cancers


Conference name: 2nd International conference on pathology
Short name: Pathology 2019
Venue : Paris,France | July 5-6,2019
URL: https://bit.ly/2GS09CI



The high-dose chemotherapy or radiation used to kill blood cancer cells also kills healthy bone marrow.  Stem cell transplants help restore the bone marrow’s ability to produce blood cells. In some cases, therapy followed by stem cell replacement cures the cancer.Blood cancer treatment usually starts with chemotherapy, either alone or with other drugs and treatments. Experts often disagree about which treatments to use. Stem cell transplants are expensive, risky, and usually recommended when chemotherapy fails. However, some cancer centers are trying stem cell transplants as a first treatment. 



Stem cells can come from several places. Bone marrow transplants replace diseased marrow with cancer-free marrow. Peripheral stem cell transplants use stem cells collected from the bloodstream. Transplants can involve the patient’s own cells (autologous) or cells from a donor (allogeneic).

Collecting bone marrow requires placing the donor under anesthesia then using a strong needle to draw marrow from the hip bone. This takes 1-2 hours in an operating room.  For several days before donating peripheral blood stem cells, donors take special drug shots to boost stem cell levels in the bloodstream. Then the donor is connected to a machine that filters the stem cells from the donor’s blood and returns the rest.

To know more about Pathology and its Applications do attend International Conference on Pathology 2019 http://pathology.alliedacademies.com/

Contact
KRISTIE NOVA
Program Director | PATHOLOGY 2019
Phone: (44) 20 3769 1755
Email: pathology(at)alliedannualsummit(dot)com