Tendon pathology in hypercholesterolaemia patients: Epidemiology, pathogenesis and management

Conference name: 2nd International conference on pathology

Short name: Pathology 2019

Venue : Paris,France| July 5-6,2019

URL:: https://bit.ly/2GS09CI

Tendon pathology is a general term used to describe a group of musculoskeletal conditions related to tendons and surrounding structures. There is only limited evidence available regarding the exact aetiology and natural history of tendon pathology. In hypercholesterolaemia environments, lipids could accumulate within the extracellular matrix of the tendon and thus affect the mechanical properties of the tendon. Current evidence suggested that hypercholesterolaemia was an important risk factor in the development and progression of tendon pathology. The severity of hypercholesterolaemia was correlated with the severity of tendon pathology.

Published link: https://doi.org/10.1016/j.jot.2018.07.003

To know more about Pathology and its Applications do attend International Conference on Pathology 2019 http://pathology.alliedacademies.com/

 Contact

KRISTIE NOVA

Program Director | PATHOLOGY 2019

Phone: (44) 20 3769 1755

Email: pathology@alliedannualsummit.com

The Effect of Muscle Loading on Skeletal Muscle Regenerative Potential: An Update of Current Research Findings Relating to Aging and Neuromuscular Pathology

Conference name: 2nd International conference on pathology

Short name: Pathology 2019

Venue : Paris,France| July 5-6,2019

URL:: https://bit.ly/2GS09CI

Skeletal muscle is a dynamic tissue with a remarkable ability to continuously respond to environmental stimuli. Among its adaptive responses is the widely investigated ability of skeletal muscle to regenerate after loading or injury or both. Although significant basic science efforts have been dedicated to better understand the underlying mechanism controlling skeletal muscle regeneration, there has been relatively little impact in the clinical approaches used to treat skeletal muscle injuries and wasting. The purpose of this review article is to provide an overview of the basic biology of satellite cell function in response to muscle loading and to relate these findings in the context of aging and neuromuscular pathology for the rehabilitation medicine specialist.

To know more about Pathology and its Applications do attend International Conference on Pathology 2019 http://pathology.alliedacademies.com/

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KRISTIE NOVA

Program Director | PATHOLOGY 2019

Phone: (44) 20 3769 1755

Email: pathology@alliedannualsummit.com

Neurofibrillary pathology: Current status and research perspectives

Conference name: 2nd International conference on pathology

Short name: Pathology 2019

Venue : Paris,France| July 5-6,2019

URL:: https://bit.ly/2GS09CI

The neurofibrils seen in the light microscope are shown, by electron microscopy, to be heterogeneous structures, formed of neurotubules and neurofilaments. A variety of pathological conditions (especially, presenile and senile dementia) are characterized by the presence of neurofibrillary tangles, formed either of paired helical filaments or of single filaments. The morphology, distribution and biochemistry of these various fibrillary structures is reviewed. 

Published link: https://doi.org/10.1016/0047-6374(79)90125-8

Particular attention is devoted to the assembly of neurotubules, to the mechanism of action of drugs which prevent assembly, and to possible implications for the experimental induction of neurofibrillary pathology. Of central importance in the arguments is the emphasis on the normal neurofibrillary structures being single forms of pleomorphic proteins. The healthy neuron assembles these proteins into the required form as is necessary for the needs of that neuron. Interference with this process in neuronal cell biology may lead to the deposition of neurofibrillary tangles. On the basis of the morphological and biochemical evidence, several approaches to the experimental study of neurofibrillary pathology are proposed.

To know more about Pathology and its Applications do attend International Conference on Pathology 2019 http://pathology.alliedacademies.com/

 Contact

KRISTIE NOVA

Program Director | PATHOLOGY 2019

Phone: (44) 20 3769 1755

Email: pathology@alliedannualsummit.com

Immunohistochemical examination using the pericyte marker myosin 1B in a perivascular myoid tumor of soft tissue with definitive pericytic differentiation

Conference name: 2nd International conference on pathology

Short name: Pathology 2019

Venue : Paris,France| July 5-6,2019

URL:: https://bit.ly/2GS09CI

Immunohistochemical staining demonstrated that the tumor cells were positive for αSMA (Fig. 1d) and MYO1B (Fig. 1e) while negative for hCD (Fig. 1f). Additional immunohistochemical staining revealed that the tumor cells were negative for desmin, CD34, and STAT6 (Fig. S1b–d). β‐catenin expression in the nuclei was not detected, unlike for sinonasal glomangiopericytomas (Fig. S1e). The present tumor was shown to be entirely composed of αSMA(+)MYO1B(+)hCD(−) tumor cells with pericytic features, indicating that the tumor in question was a perivascular myoid tumor with definitive pericytic differentiation. 

   

Publisher link: 

https://doi.org/10.1111/pin.12777

Currently, the term “glomangiopericytoma” has been used for sinonasal glomangiopericytomas, which arise exclusively from the nasal cavity and paranasal sinus.3To the best of our knowledge, only two glomangiopericytoma cases occurring outside the nasal cavity and paranasal sinus have been reported after the Granter et al.2 paper was published.4, 5 These two cases were diagnosed as glomangiopericytomas based on histological findings and αSMA expression; however, pericytic features of tumor cells in those two cases could not be demonstrated.

Although we had not encountered glomus tumors such as the present case that were entirely composed of αSMA(+)MYO1B(+)hCD(−) cells, it may be a special glomus tumor in which tumor cells are fully differentiated into pericytes. Therefore, it is necessary to investigate whether glomangiopericytoma‐like tumors arising from a distal extremity should be separated from glomus tumors as a distinct clinicopathological entity.

To know more about Pathology and its Applications do attend International Conference on Pathology 2019 http://pathology.alliedacademies.com/

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KRISTIE NOVA

Program Director | PATHOLOGY 2019

Phone: (44) 20 3769 1755Email: pathology@alliedannualsummit.com

Penn researchers cure nine HCV patients following heart transplants from infected donors

Conference name: 2nd International conference on pathology

Short name: Pathology 2019

Venue : Paris,France| July 5-6,2019

URL:: https://bit.ly/2GS09CI

Nine patients at Penn Medicine have been cured of the Hepatitis C virus (HCV) following lifesaving heart transplants from deceased donors who were infected with the disease, according to a study published in the American Journal of Transplantation. The results highlight the potential for expanding the use of HCV-infected organs, including hearts, to broaden the donor pool for the more than 100,000 Americans currently on a transplant waitlist.

In 2017, Penn Medicine launched a clinical trial to test the effect of transplanting hearts from donors with HCV into patients on the transplant waitlist who do not have the virus. Researchers modeled the clinical trial, known as USHER, after an innovative Penn Medicine-led study that involved transplanting HCV-infected kidneys (known as THINKER), and then treating the recipients with an antiviral therapy to eradicate the virus after transplantation. In both studies, all the patients who completed the antiviral therapy regimen have been cured of their contracted HCV.

Source: https://www.pennmedicine.org/news/news-releases/2019/february/penn-team-eradicates-hepatitis-c-in-nine-patients-following-lifesaving-heart-transplants

"For decades, Hepatitis C-infected hearts were often discarded - and the few people who received these organs were found to have a significantly lower rate of survival," said Peter Reese, MD, MSCE, an associate professor of Medicine and Epidemiology. "Our trial provides fresh evidence to show that new antiviral treatments for HCV work well in immunosuppressed patients, which has the potential to really impact the field of transplantation. These preliminary results suggest that we should make it a priority to expand the use of good-quality HCV-infected organs."

To know more about Pathology and its Applications do attend International Conference on Pathology 2019 http://pathology.alliedacademies.com/

Contact

KRISTIE NOVA

Program Director | PATHOLOGY 2019

Phone: (44) 20 3769 1755Email: pathology@alliedannualsummit.com

Reproducibility study on myocardial strain

Conference name: 2nd International conference on pathology

Short name: Pathology 2019

Venue : Paris,France| July 5-6,2019

URL:: https://bit.ly/2GS09CI

Myocardial strain is a well validated parameter for estimating left ventricular (LV) performance. The aim of our study was to evaluate the inter-study as well as intra- and interobserver reproducibility of fast-SENC derived myocardial strain. Eighteen subjects (11 healthy individuals and 7 patients with heart failure) underwent a cardiac MRI examination including fast-SENC acquisition for evaluating left ventricular global longitudinal (GLS) and circumferential strain (GCS) as well as left ventricular ejection fraction (LVEF). The examination was repeated after 63 [range 49‒87] days and analyzed by two experienced observers. Ten datasets were repeatedly assessed after 1 month by the same observer to test intraobserver variability.

AUTHOR-  Sorin Giusca

 The reproducibility was measured using the intraclass correlation coefficient (ICC) and Bland-Altman analysis. Patients with heart failure demonstrated reduced GLS and GCS compared to healthy controls (−15.7 ± 3.7 vs. −20.1 ± 1.4; p = 0.002 for GLS and −15.3 ± 3.7 vs. −21.4 ± 1.1; p = 0.001 for GCS). The test-retest analysis showed excellent ICC for LVEF (0.92), GLS (0.94) and GCS (0.95). GLS exhibited excellent ICC (0.99) in both intra- and interobserver variability analysis with very narrow limits of agreement (−0.6 to 0.5 for intraobserver and −1.3 to 0.96 for interobserver agreement). 

Similarly, GCS showed excellent ICC (0.99) in both variability analyses with narrow limits of agreement (−1.1 to 1.2 for intraobserver and −1.7 to 1.3 for interobserver agreement), whereas LVEF showed larger limits of agreement (−14.4 to 10.1). The analysis of fast-SENC derived myocardial strain using cardiac MRI provides a highly reproducible method for assessing LV functional performance.

To know more about Pathology and its Applications do attend International Conference on Pathology 2019 http://pathology.alliedacademies.com/

 Contact

KRISTIE NOVA

Program Director | PATHOLOGY 2019

Phone: (44) 20 3769 1755

Email: pathology@alliedannualsummit.com

Breast cancer global tumor biomarkers

Conference name: 2nd International conference on pathology

Short name: Pathology 2019

Venue : Paris,France| July 5-6,2019

URL: https://bit.ly/2GS09CI

Biomarker analysis of invasive breast carcinoma is useful for prognosis, as surrogate for molecular subtypes of breast cancer, and prediction of response to adjuvant and neoadjuvant systemic therapies. Breast cancer intratumoral heterogeneity is incompletely studied. Comprehensive biomarker analysis of estrogen receptor (ER), progesterone receptor (PR), HER2, and Ki67 labeling index was performed on each tissue block of 100 entirely submitted breast tumors in 99 patients. Invasive carcinoma and in situ carcinoma was scored using semiquantitative histologic score (H-score) for ER and PR, HER2 expression from 0 to 3+, and percentage positive cells for Ki67. 

Core biopsy results were compared with surgical excision results, invasive carcinoma was compared with in situ carcinoma, and interblock tumoral heterogeneity was assessed using measures of dispersion (coefficient of variation and quartile coefficient of dispersion). Overall concordance between core biopsy and surgical excision was 99% for ER and 95% for PR. Mean histologic score of ER was significantly lower in invasive carcinoma between core biopsy and surgical excision (p = 0.000796). Intratumoral heterogeneity was higher for PR than for ER (mean coefficient of variation for ER 0.08 stdv 0.13 vs. PR 0.26 stdv 0.41). Ki67 labeling index was significantly higher in invasive carcinoma as compared with associated ductal carcinoma in situ on surgical resection specimen (p ≤ 0.0001). Ki67 hotspots were identified in 47% of cases. 

AUTHOUR- Beth Z. Clark

                                         

Of 52 HER2 negative cases on core biopsy, 10 were scored as equivocal on surgical resection. None (0/10) were amplified by Her-2/neu fluorescence in situ hybridization. Overall, biomarkers on core biopsy showed concordance with the surgical excision specimen in the vast majority of cases. Biomarker expression of in situ closely approximates associated invasive carcinoma. Intratumoral heterogeneity of PR is greater than ER. Biomarker expression on diagnostic core biopsy or single tumor block is representative of breast carcinoma as a whole in most cases and is appropriate for clinical decision-making.

To know more about Pathology and its Applications do attend International Conference on Pathology 2019 http://pathology.alliedacademies.com/

 Contact

KRISTIE NOVA

Program Director | PATHOLOGY 2019

Phone: (44) 20 3769 1755

Email: pathology@alliedannualsummit.com

The pathology of bicuspid aortic valve: Novel research perspectives.

Conference name: 2nd International conference on pathology

Short name: Pathology 2019

Venue : Paris,France| July 5-6,2019

URL:: https://bit.ly/2GS09CI

Bicuspid semilunar valve is the most prevailing cardiac valvular malformation. it relates to a high rate of long-run morbidity together with development of hardening semilunar valve disorder, aortal regurgitation and concomitant pectoral aneurysm and dissection. Recently, basic and travel studies have known some key processes concerned with the development of bicuspid semilunar valve and its morbidity.

Stenosis of Bicuspid valve

 The increase of semilunar valve disorder and pectoral aneurysm and dissection is the results of complicated interactions between genotypes, environmental risk factors and specific haemodynamic conditions created by bicuspid semilunar valve anatomy. Herein, we tend to review the pathobiology of bicuspid semilunar valve with a special emphasis on travel aspects of those basic findings. Vital however unresolved issues within the pathology of bicuspid semilunar valve and pectoral aneurysm and dissection area unit mentioned, together with the molecular processes concerned.

To know more about Pathology and its Applications do attend International Conference on Pathology 2019 http://pathology.alliedacademies.com/

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KRISTIE NOVA

Program Director | PATHOLOGY 2019

Phone: (44) 20 3769 1755

Email: pathology@alliedannualsummit.com

Mismatch repair deficiency in endometrial cancers

Conference name: 2nd International conference on pathology

Short name: Pathology 2019

Venue : Paris,France| July 5-6,2019

URL:: https://bit.ly/2GS09CI

Mismatch repair deficiency represents a biomarker of immuno response and a phenotypic feature of kill syndrome-associated mucosal cancers. employing a targeted next-generation sequencing assay, we have a tendency to diagonized molecular symptoms of mate repair deficiency, specifically insertion and deletion mutations in mononucleotide repeats, and established thresholds for the amount of such mutations to classify mucosal cancers as mismatch repair deficient, proficient, or indeterminate. Sequencing classification was compared to the loss of MLH1, MSH2, MSH6, or PMS2 expression by assay.

                                      

a complete of 259 mucosal cancers were classified by sequencing as mismatch repair deficient (n = 48, 19%), practiced (n = 199, 77%), or indeterminate (n = 12, 5%). Sequencing findings were concordant with loss of expression of a minimum of one mismatch repair macromolecule in forty seven of forty eight (98%) cases classified as deficient and preserved expression of all four proteins in a hundred ninety of 199 (95%) cases classified as good. Of the twelve cases classified as indeterminate, seven (58%) incontestable mismatch repair macromolecule loss.

Overall, targeted next-generation sequencing exhibited a high rate of concordance with assay for mate repair deficiency; however, sequencing was indeterminate during a few cases and discovered a false negative rate of fifty. though we suggest implementation of a mismatch repair deficiency formula for laboratories activity next-generation sequencing cancer panels, assay remains an economical screening methodology for mismatch repair deficiency in endometrial carcinoma.

To know more about Pathology and its Applications do attend International Conference on Pathology 2019 http://pathology.alliedacademies.com/

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KRISTIE NOVA

Program Director | PATHOLOGY 2019

Phone: (44) 20 3769 1755

Email: pathology@alliedannualsummit.com

Diagnosis of nonalcoholic steatohepatitis

Conference name: 2nd International conference on pathology

Short name: Pathology 2019

Venue: Paris, France| July 5-6,2019

URL: https://bit.ly/2GS09CI

The histological analysis, most typically in the variety of liver biopsy, remains the gold standard in analysis of nonalcoholic fatty liver disease (NAFLD). Histological analysis was fundamental to the initial studies that introduced and outlined the thought of fatty liver as a disease. Currently, liver biopsy in NAFLD serves multiple roles: confirmation (or exclusion) of the diagnosis; distinction of steatohepatitis from “simple steatosis”; assessment of extent of necroinflammatory activity, fibrosis, and field alterations.

Histopathologic studies have underscored the things that not all fat and/or diabetic individuals with elevated liver tests have liver disease; for example, hepatic glycogenosis and hepatosclerosis are seen in diabetics, and different vital liver diseases are documented. The diagnostic assay studies have documented lesions of steatosis or steatohepatitis within the patient teams or clinical settings, like lean persons, individuals with traditional liver tests, patients taking sure medications, patients with co-existent serologically-diagnosed disease, and medical specialty patients.

Biopsy studies have shown that the lesions of nash might or might not persist in cirrhosis; prior proof of writer on liver biopsy is a benchmark for the concept that several cases of otherwise cryptogenic cirrhosis developed from NAFLD/NASH. Liver biopsy remains a major feature of studies delineating long-run outcome of NAFLD, some of which have shown that “simple steatosis” isn't always non-progressive and benign. Finally, investigators have noted correlations of projected pathophysiologic processes in nash with histological things.

To know more about Pathology and its Applications do attend International Conference on Pathology 2019 http://pathology.alliedacademies.com/

Contact 
KRISTIE NOVA
Program Director | PATHOLOGY 2019
Phone: (44) 20 3769 1755
Email: pathology@alliedannualsummit.com

The identification of non-small cell carcinoma within the molecular era

Conference name: 2nd International conference on pathology

Short name: Pathology 2019

Venue : Paris,France| July 5-6,2019

URL:: https://bit.ly/2GS09CI

Lung tumour is the leading reason for cancer mortality for both genders in the u.  s. and throughout the globe. several of these tumors are being diagnosed with minimally invasive cause leading to little samples. there's a necessity to extract an increasing quantity of therapeutic and prognostic data from progressively smaller samples. Collaboration among clinicians and pathologists is required to provide a comprehensive final diagnosing in patients with carcinoma. This collaboration facilitates sorting of tiny samples for supportive studies together with molecular testing. What follows represents a review of the present required testing for carcinoma specimens, an example of an algorithm recently utilized at the Cleveland Clinic so all needed tests will be performed even on the tiniest of specimens and suggestions on how pathologists could approach this new era of “doing a lot of with less”.

Cancer is a major public issues in the u.  s. and lots of alternative parts of the globe. One in 4 deaths in the u.  s. is because of cancer. in this article, we offer the expected numbers of latest cancer cases and deaths in 2018 nationwide and by state, also as an outline of current cancer statistics exploitation information through 2018, together with incidence, mortality, and survival rates and trends. we additionally estimate the overall range of deaths averted as a result of the decline in cancer death rates since the early 1990s, and supply the particular reported  numbers of deaths in 2018 by age for the 10 leading causes of death and also the 5 leading cancer sorts.

To know more about Pathology and its Applications do attend International Conference on Pathology 2019 http://pathology.alliedacademies.com/

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Contact

KRISTIE NOVA

Program Director | PATHOLOGY 2019

Phone: (44) 20 3769 1755

Email: pathology@alliedannualsummit.com